Modeling of a propagation mechanism of infectious prion protein; a hexamer as the minimum infectious unit.
Biochem Biophys Res Commun
; 361(3): 789-93, 2007 Sep 28.
Article
in En
| MEDLINE
| ID: mdl-17678874
ABSTRACT
To construct a new model of the propagation mechanism of infectious scrapie-type prion protein (PrP(Sc)), here we conducted a disruption simulation of a PrP(Sc) nonamer using structure-based molecular dynamics simulation method based on a hypothetical PrP(Sc) model structure. The simulation results showed that the nonamer disrupted in cooperative manners into monomers via two significant intermediate states (1) a nonamer with a partially unfolded surface trimer and (2) a hexamer and three monomers. Dimers and trimers were rarely observed. Then, we propose a new PrP(Sc) propagation mechanism where a hexamer plays an essential role as a minimum infectious unit.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Models, Molecular
/
PrPSc Proteins
Language:
En
Journal:
Biochem Biophys Res Commun
Year:
2007
Document type:
Article
Affiliation country:
Japan