Continuous intra-arterial application of substance P induces signs and symptoms of experimental complex regional pain syndrome (CRPS) such as edema, inflammation and mechanical pain but no thermal pain.

Gradl, G; Finke, B; Schattner, S; Gierer, P; Mittlmeier, T; Vollmar, B

Gradl, G; Finke, B; Schattner, S; Gierer, P; Mittlmeier, T; Vollmar, B.

Affiliation

Gradl G; Institute for Experimental Surgery, University of Rostock, Schillingallee 69a, 18055 Rostock, Germany.

Neuroscience ; 148(3): 757-65, 2007 Sep 07.

Article in En | MEDLINE | ID: mdl-17686587

Subject(s)

Complex Regional Pain Syndromes/metabolism; Edema/metabolism; Hyperalgesia/metabolism; Neurogenic Inflammation/metabolism; Substance P/metabolism; Animals; Chemotaxis, Leukocyte/drug effects; Chemotaxis, Leukocyte/physiology; Complex Regional Pain Syndromes/chemically induced; Complex Regional Pain Syndromes/physiopathology; Disease Models, Animal; Edema/chemically induced; Edema/physiopathology; Endothelial Cells/drug effects; Hyperalgesia/chemically induced; Hyperalgesia/physiopathology; Hypesthesia/metabolism; Hypesthesia/physiopathology; Infusion Pumps, Implantable; Injections, Intra-Arterial/adverse effects; Male; Microcirculation/drug effects; Microcirculation/pathology; Microcirculation/physiopathology; Neurogenic Inflammation/chemically induced; Neurogenic Inflammation/physiopathology; Pain Measurement/drug effects; Pain Threshold/drug effects; Pain Threshold/physiology; Physical Stimulation; Rats; Rats, Sprague-Dawley; Substance P/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Substance P / Neurogenic Inflammation / Complex Regional Pain Syndromes / Edema / Hyperalgesia Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Neuroscience Year: 2007 Document type: Article Affiliation country: Germany Country of publication: United States

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