A new experimental model of isolated perfused pig liver to support acute hepatic failure.
Transplant Proc
; 39(6): 2028-30, 2007.
Article
in En
| MEDLINE
| ID: mdl-17692683
ABSTRACT
Liver transplantation still represents the only effective treatment for patients with liver failure, but many patients die while awaiting transplantation, even though many attempts have been made to increase the organ procurement rates and to partially support hepatic function in recent years. Our aim was to design an "open" ex vivo perfused liver model to simplify liver support using an isolated porcine liver perfused with arterial and portal blood from the recipient pig, while monitoring the metabolic capacity of the supporting graft. It was possible to perfuse the isolated liver for 6 hours as a bridging procedure with satisfactory hemodynamic homeostasis controlled by software biofeedbacks.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Liver Failure, Acute
/
Liver
Limits:
Animals
/
Humans
Language:
En
Journal:
Transplant Proc
Year:
2007
Document type:
Article
Affiliation country:
Italy