The CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections.

Watts, Joel C; Drisaldi, Bettina; Ng, Vivian; Yang, Jing; Strome, Bob; Horne, Patrick; Sy, Man-Sun; Yoong, Larry; Young, Rebecca; Mastrangelo, Peter; Bergeron, Catherine; Fraser, Paul E; Carlson, George A; Mount, Howard T J; Schmitt-Ulms, Gerold; Westaway, David

Watts, Joel C; Drisaldi, Bettina; Ng, Vivian; Yang, Jing; Strome, Bob; Horne, Patrick; Sy, Man-Sun; Yoong, Larry; Young, Rebecca; Mastrangelo, Peter; Bergeron, Catherine; Fraser, Paul E; Carlson, George A; Mount, Howard T J; Schmitt-Ulms, Gerold; Westaway, David.

Affiliation

Watts JC; Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Canada.

EMBO J ; 26(17): 4038-50, 2007 Sep 05.

Article in En | MEDLINE | ID: mdl-17703189

Subject(s)

Brain/metabolism; Glycoproteins/physiology; Nerve Tissue Proteins/metabolism; Neurons/metabolism; PrPC Proteins/metabolism; Prion Diseases/metabolism; Prions/metabolism; Amino Acid Sequence; Animals; Cell Line, Tumor; Cerebellum/metabolism; GPI-Linked Proteins; Glycoproteins/genetics; Hippocampus/metabolism; Mice; Molecular Sequence Data; Nerve Tissue Proteins/genetics; Protein Binding

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Prions / Glycoproteins / Prion Diseases / PrPC Proteins / Nerve Tissue Proteins / Neurons Limits: Animals Language: En Journal: EMBO J Year: 2007 Document type: Article Affiliation country: Canada Country of publication: United kingdom

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