Mitochondrially targeted effects of berberine [Natural Yellow 18, 5,6-dihydro-9,10-dimethoxybenzo(g)-1,3-benzodioxolo(5,6-a) quinolizinium] on K1735-M2 mouse melanoma cells: comparison with direct effects on isolated mitochondrial fractions.

Pereira, Gonçalo C; Branco, Ana F; Matos, Júlio A C; Pereira, Sandro L; Parke, Donna; Perkins, Edward L; Serafim, Teresa L; Sardão, Vilma A; Santos, Maria S; Moreno, Antonio J M; Holy, Jon; Oliveira, Paulo J

Pereira, Gonçalo C; Branco, Ana F; Matos, Júlio A C; Pereira, Sandro L; Parke, Donna; Perkins, Edward L; Serafim, Teresa L; Sardão, Vilma A; Santos, Maria S; Moreno, Antonio J M; Holy, Jon; Oliveira, Paulo J.

Affiliation

Pereira GC; Center for Neurosciences and Cell Biology, Department of Zoology, University of Coimbra, Coimbra, Portugal.

J Pharmacol Exp Ther ; 323(2): 636-49, 2007 Nov.

Article in En | MEDLINE | ID: mdl-17704354

Subject(s)

Berberine/pharmacology; Mitochondria/drug effects; Adenosine Triphosphatases/metabolism; Animals; Berberine/pharmacokinetics; Calcium/metabolism; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone/pharmacology; Cell Proliferation/drug effects; Cells, Cultured; DNA, Mitochondrial/analysis; Energy Metabolism/drug effects; Male; Melanoma, Experimental/pathology; Membrane Potentials/drug effects; Mice; Mitochondrial Membrane Transport Proteins/drug effects; Mitochondrial Permeability Transition Pore; Oxidative Stress/drug effects; Rats; Rats, Wistar; Reactive Oxygen Species/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Berberine / Mitochondria Limits: Animals Language: En Journal: J Pharmacol Exp Ther Year: 2007 Document type: Article Affiliation country: Portugal Country of publication: United States

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