Synthesis and characterization of nonsteroidal glucocorticoid receptor modulators for multiple myeloma.
J Med Chem
; 50(19): 4699-709, 2007 Sep 20.
Article
in En
| MEDLINE
| ID: mdl-17705362
ABSTRACT
Structure-activity relationship studies centered around 3'-substituted (Z)-5-(2'-(thienylmethylidene))1,2-dihydro-9-hydroxy-10-methoxy-2,2,4-trimethyl-5H-chromeno[3,4-f]quinolines are described. A series of highly potent and efficacious selective glucocorticoid receptor modulators were identified with in vitro activity comparable to dexamethasone. In vivo evaluation of these compounds utilizing a 28 day mouse tumor xenograft model demonstrated efficacy equal to dexamethasone in the reduction of tumor volume.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quinolines
/
Benzopyrans
/
Receptors, Glucocorticoid
/
Multiple Myeloma
/
Antineoplastic Agents
Limits:
Animals
/
Humans
Language:
En
Journal:
J Med Chem
Journal subject:
QUIMICA
Year:
2007
Document type:
Article
Affiliation country:
United States