Decreased gene expression of neuropeptide Y and its receptors in hippocampal regions during ethanol withdrawal in rats.
Neurosci Lett
; 424(3): 160-4, 2007 Sep 13.
Article
in En
| MEDLINE
| ID: mdl-17723274
ABSTRACT
Ethanol withdrawal is associated with neuronal hyperexcitability and increased hippocampal glutamate release. Neuropeptide Y (NPY) appears to play an important role in regulation of hippocampal neuronal excitability by inhibiting glutamate release. Expression of NPY and its receptors Y1, Y2, and Y5 was studied in hippocampal areas of rats during ethanol withdrawal after repeated intragastric ethanol administration for 2 or 4 days using in situ hybridization. Withdrawal was associated with decreased hippocampal expression of NPY and each of its receptors, particularly Y2, after 2 and/or 4 days of ethanol compared to control rats. These data suggest that the hippocampal NPY system is downregulated during ethanol withdrawal and these neuroadaptational changes could play a role in mediating withdrawal hyperexcitability.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Substance Withdrawal Syndrome
/
Neuropeptide Y
/
Down-Regulation
/
Receptors, Neuropeptide Y
/
Ethanol
Limits:
Animals
Language:
En
Journal:
Neurosci Lett
Year:
2007
Document type:
Article
Affiliation country:
Denmark