Lactogens promote beta cell survival through JAK2/STAT5 activation and Bcl-XL upregulation.

Fujinaka, Yuichi; Takane, Karen; Yamashita, Hiroko; Vasavada, Rupangi C

Fujinaka, Yuichi; Takane, Karen; Yamashita, Hiroko; Vasavada, Rupangi C.

Affiliation

Fujinaka Y; Division of Endocrinology, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.

J Biol Chem ; 282(42): 30707-17, 2007 Oct 19.

Article in En | MEDLINE | ID: mdl-17728251

Subject(s)

Diabetes Mellitus, Experimental/metabolism; Insulin-Secreting Cells/metabolism; Janus Kinase 2/metabolism; Placental Lactogen/metabolism; STAT5 Transcription Factor/metabolism; bcl-X Protein/metabolism; Animals; Anti-Inflammatory Agents/toxicity; Cell Death/drug effects; Cell Line, Tumor; Cell Survival/drug effects; Cell Survival/genetics; Cytoprotection/drug effects; Cytoprotection/genetics; Dexamethasone/toxicity; Diabetes Mellitus, Experimental/genetics; Diabetes Mellitus, Experimental/therapy; Genes, Dominant; Insulin/genetics; Insulin-Secreting Cells/pathology; Janus Kinase 2/antagonists & inhibitors; Janus Kinase 2/genetics; Mice; Mice, Transgenic; Mutation; Placental Lactogen/genetics; Prolactin/genetics; Prolactin/metabolism; Promoter Regions, Genetic/genetics; RNA, Small Interfering/metabolism; Rats; STAT5 Transcription Factor/genetics; Signal Transduction; Up-Regulation/drug effects; Up-Regulation/genetics; bcl-X Protein/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Placental Lactogen / Diabetes Mellitus, Experimental / Insulin-Secreting Cells / STAT5 Transcription Factor / Bcl-X Protein / Janus Kinase 2 Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Biol Chem Year: 2007 Document type: Article Affiliation country: United States Country of publication: United States

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