Reducing amyloid plaque burden via ex vivo gene delivery of an Abeta-degrading protease: a novel therapeutic approach to Alzheimer disease.

Hemming, Matthew L; Patterson, Michaela; Reske-Nielsen, Casper; Lin, Ling; Isacson, Ole; Selkoe, Dennis J

Hemming, Matthew L; Patterson, Michaela; Reske-Nielsen, Casper; Lin, Ling; Isacson, Ole; Selkoe, Dennis J.

Affiliation

Hemming ML; Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America.

PLoS Med ; 4(8): e262, 2007 Aug.

Article in En | MEDLINE | ID: mdl-17760499

Subject(s)

Alzheimer Disease/therapy; Genetic Therapy/methods; Neprilysin/metabolism; Plaque, Amyloid/metabolism; Alzheimer Disease/genetics; Alzheimer Disease/metabolism; Amyloid beta-Peptides/metabolism; Animals; CHO Cells; Cell Line; Cells, Cultured; Cricetinae; Cricetulus; Enzyme-Linked Immunosorbent Assay; Genetic Vectors/genetics; Gliosis/genetics; Humans; Immunoblotting; Immunohistochemistry; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neprilysin/genetics; Transfection; Transplants

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Genetic Therapy / Neprilysin / Plaque, Amyloid / Alzheimer Disease Limits: Animals / Humans Language: En Journal: PLoS Med Journal subject: MEDICINA Year: 2007 Document type: Article Affiliation country: United States Country of publication: United States

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