Preliminary report of the effect of high-dose adjuvant intensity modulated radiation therapy on the sural nerve graft for cavernosal nerve sacrifice after radical prostatectomy.
Am J Clin Oncol
; 30(4): 395-400, 2007 Aug.
Article
in En
| MEDLINE
| ID: mdl-17762440
ABSTRACT
PURPOSE:
A sural nerve graft may replace a killed cavernosal nerve. The effect of intensity-modulated radiation therapy (IMRT) on function of the graft has not been reported. MATERIALS ANDMETHODS:
Between 1998 and 2001, 8 patients (9 nerve grafts) were treated with postoperative IMRT (mean dose, 70 Gy). Two patients had neoadjuvant Lupron 30 mg 2 months prior to radiation. Potency was defined as ability to achieve spontaneous erection sufficient for vaginal penetration. Median follow-up was 31.6 months.RESULTS:
Five patients (62.5%) who had erectile function after prostatectomy preserved spontaneous erectile function after radiation. Of these, 3 patients had both nerves resected (two receiving unilateral grafts and one receiving bilateral grafts) and 2 others had one graft and one nerve preserved. The impotent patients were impotent after surgery.CONCLUSION:
High-dose postprostatectomy IMRT does not place sural nerve grafts at greater risk for failure. Larger numbers of patients are needed to confirm these encouraging, preliminary findings.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Penis
/
Prostatic Neoplasms
/
Sural Nerve
Limits:
Aged
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Am J Clin Oncol
Year:
2007
Document type:
Article
Affiliation country:
United States