Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock.

Vogl, Thomas; Tenbrock, Klaus; Ludwig, Stephan; Leukert, Nadja; Ehrhardt, Christina; van Zoelen, Marieke A D; Nacken, Wolfgang; Foell, Dirk; van der Poll, Tom; Sorg, Clemens; Roth, Johannes

Vogl, Thomas; Tenbrock, Klaus; Ludwig, Stephan; Leukert, Nadja; Ehrhardt, Christina; van Zoelen, Marieke A D; Nacken, Wolfgang; Foell, Dirk; van der Poll, Tom; Sorg, Clemens; Roth, Johannes.

Affiliation

Vogl T; Institute of Experimental Dermatology, University of Münster, D-48129 Münster, Germany.

Nat Med ; 13(9): 1042-9, 2007 Sep.

Article in En | MEDLINE | ID: mdl-17767165

Subject(s)

Calgranulin A/physiology; Calgranulin B/physiology; Endotoxins/toxicity; Shock, Septic/physiopathology; Toll-Like Receptor 4/physiology; Animals; Calgranulin A/deficiency; Calgranulin B/genetics; Cell Line, Tumor; Cells, Cultured; Flow Cytometry; Humans; Ligands; Lipopolysaccharides/toxicity; Mice; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Pulmonary Alveoli/cytology; Pulmonary Alveoli/physiology; Shock, Septic/genetics; Tumor Necrosis Factor-alpha/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Shock, Septic / Calgranulin A / Calgranulin B / Endotoxins / Toll-Like Receptor 4 Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Nat Med Journal subject: BIOLOGIA MOLECULAR / MEDICINA Year: 2007 Document type: Article Affiliation country: Germany

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