Intestinal toxicity induced by 5-fluorouracil in pigs: a new preclinical model.
Chemotherapy
; 53(5): 344-55, 2007.
Article
in En
| MEDLINE
| ID: mdl-17785971
ABSTRACT
BACKGROUND:
The goal of this study was to develop an animal model of intestinal injury induced by 5-fluorouracil (5-FU) in pigs.METHODS:
Six domestic pigs were used as control (healthy group) and another 6 malnourished pigs orally received 5-FU (treated group). After 4 weeks of treatment, pigs were sacrificed and jejunum, ileum and colon were isolated for histological, immunological and biochemical analyses.RESULTS:
5-FU caused a decrease in the intestinal mass. Disaccharidase, and phosphate alkaline activities, and glutathione redox cycle were disrupted by 5-FU. Histopathological alterations in the crypts and villous were greater in the small intestine than in the colon. 5-FU decreased the number of peripheral and intestinal leukocytes, promoting an increase in T-cytotoxic cells and a decrease in T-helper and B cells.CONCLUSION:
This pig model of intestinal dysfunction closely mimics the common side effects of cancer chemotherapy in humans, and provides a useful tool for evaluating novel antimucotoxic agents.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Swine
/
Models, Animal
/
Fluorouracil
/
Intestines
Limits:
Animals
Language:
En
Journal:
Chemotherapy
Year:
2007
Document type:
Article
Affiliation country:
Spain