Atherosclerosis is attenuated by limiting superoxide generation in both macrophages and vessel wall cells.

Vendrov, Aleksandr E; Hakim, Zeenat S; Madamanchi, Nageswara R; Rojas, Mauricio; Madamanchi, Chaitanya; Runge, Marschall S

Vendrov, Aleksandr E; Hakim, Zeenat S; Madamanchi, Nageswara R; Rojas, Mauricio; Madamanchi, Chaitanya; Runge, Marschall S.

Affiliation

Vendrov AE; Department of Medicine, University of North Carolina at Chapel Hill, 3033 Old Clinic Building, Chapel Hill, NC 27599-7005, USA.

Arterioscler Thromb Vasc Biol ; 27(12): 2714-21, 2007 Dec.

Article in En | MEDLINE | ID: mdl-17823367

Subject(s)

Atherosclerosis/prevention & control; Bone Marrow Transplantation; Endothelium, Vascular/metabolism; Macrophages/metabolism; Muscle, Smooth, Vascular/metabolism; NADPH Oxidases/metabolism; Superoxides/metabolism; Animals; Aorta/enzymology; Aorta/metabolism; Apolipoproteins E/deficiency; Apolipoproteins E/genetics; Apolipoproteins E/metabolism; Atherosclerosis/enzymology; Atherosclerosis/genetics; Atherosclerosis/metabolism; Atherosclerosis/pathology; Cell Adhesion Molecules/metabolism; Cell Proliferation; Dietary Fats/administration & dosage; Disease Models, Animal; Endothelium, Vascular/enzymology; Endothelium, Vascular/injuries; Endothelium, Vascular/pathology; Femoral Artery/enzymology; Femoral Artery/injuries; Femoral Artery/metabolism; Hyperplasia; Janus Kinase 2/metabolism; Lipoproteins, LDL/blood; Macrophages/enzymology; Macrophages/pathology; Mice; Mice, Knockout; Mitogen-Activated Protein Kinases/metabolism; Muscle, Smooth, Vascular/enzymology; Muscle, Smooth, Vascular/injuries; Muscle, Smooth, Vascular/pathology; NADPH Oxidases/deficiency; NADPH Oxidases/genetics; Oxidation-Reduction; Phosphorylation; RNA, Messenger/metabolism; STAT3 Transcription Factor/metabolism; Signal Transduction; Thrombin/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Endothelium, Vascular / Bone Marrow Transplantation / Superoxides / NADPH Oxidases / Atherosclerosis / Macrophages / Muscle, Smooth, Vascular Type of study: Prognostic_studies Language: En Journal: Arterioscler Thromb Vasc Biol Journal subject: ANGIOLOGIA Year: 2007 Document type: Article Affiliation country: United States Country of publication: United States

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