Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor.
Bioorg Med Chem Lett
; 17(19): 5472-8, 2007 Oct 01.
Article
in En
| MEDLINE
| ID: mdl-17827014
ABSTRACT
Following our previous publication describing the biological profiles, we herein describe the structure-activity relationships of a core set of quinoxalines as the hGLP-1 receptor agonists. The most potent and efficacious compounds are 6,7-dichloroquinoxalines bearing an alkyl sulfonyl group at the C-2 position and a secondary alkyl amino group at the C-3 position. These findings serve as a valuable starting point for the discovery of more drug-like small molecule agonists for the hGLP-1 receptor.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Receptors, Glucagon
Limits:
Humans
Language:
En
Journal:
Bioorg Med Chem Lett
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2007
Document type:
Article
Affiliation country:
United States