[Change of pulsatile release and luteinizing hormone response to naloxone related to testicle damage]. / Cambio en la secreción pulsátil y en la respuesta de la hormona luteinizante a la naloxona en relación con el daño testicular.
Ginecol Obstet Mex
; 75(4): 200-4, 2007 Apr.
Article
in Es
| MEDLINE
| ID: mdl-17849799
ABSTRACT
OBJECTIVE:
To compare the pulsatile release of LH, the tone of endogenous opioids and the mass of LH secreted after a naloxone infusion in healthy subjects and patients with normogonadotropic oligospermia (NO) in a model of progressive testicular damage. PATIENTS ANDMETHODS:
Pulsatile secretion of LH was analyzed in a period of 8 hours in a group of healthy subjects (group 3, n=5), in patients with NO and FSH/LH ratio <1.6 (group 1, n=5) and in patients with NO and FSH/LH ratio >1.6 (group 2, n=5). The area under the curve of LH response after naloxone infusion was also calculated.RESULTS:
Free serum testosterone concentration was lower (p < 0.01) and estradiol concentration higher in patients with NO than control subjects (1 vs. 3 p = 0.01; 2 vs. 3 p = 0.001). Frequency of pulses in group 1 was 3.33 +/- 0.57/8 h, in group 2 4 +/- 1/8 h; and in group 3 2.66 - 0.57/8 h (2 vs. 3 p < 0.01; 2 vs. 1 p = 0.05). The area under the curve after naloxone infusion was 19,300.44 +/- 11,403.31 in group 1, 5696.09 +/- 1753.44 in group 2; and 3080.97 +/- 1159.78 in group 3 (1 vs. 3 Anova p = 0.01).CONCLUSIONS:
The data indicate that patients with NO have a subclinical pantesticular failure and that the opioid tone is increased at the initial phase of testicular dysfunction, but it decreases at more advanced stages of testicular damage.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oligospermia
/
Testicular Diseases
/
Luteinizing Hormone
/
Naloxone
Type of study:
Prognostic_studies
Limits:
Humans
/
Male
Language:
Es
Journal:
Ginecol Obstet Mex
Year:
2007
Document type:
Article