Immune suppression or enhancement by CD137 T cell costimulation during acute viral infection is time dependent.

Zhang, Benyue; Maris, Charles H; Foell, Juergen; Whitmire, Jason; Niu, Liguo; Song, Jing; Kwon, Byoung S; Vella, Anthony T; Ahmed, Rafi; Jacob, Joshy; Mittler, Robert S

Zhang, Benyue; Maris, Charles H; Foell, Juergen; Whitmire, Jason; Niu, Liguo; Song, Jing; Kwon, Byoung S; Vella, Anthony T; Ahmed, Rafi; Jacob, Joshy; Mittler, Robert S.

Affiliation

Zhang B; Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA.

J Clin Invest ; 117(10): 3029-41, 2007 Oct.

Article in En | MEDLINE | ID: mdl-17853940

Subject(s)

CD4-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/immunology; Immunosuppression Therapy; Influenza, Human/immunology; Lymphocytic Choriomeningitis/immunology; Tumor Necrosis Factor Receptor Superfamily, Member 9/antagonists & inhibitors; Animals; Antibodies, Monoclonal/administration & dosage; Antibodies, Monoclonal/immunology; CD4-Positive T-Lymphocytes/drug effects; CD8-Positive T-Lymphocytes/drug effects; Humans; Interleukin-10/metabolism; Mice; Mice, Mutant Strains; Time Factors; Tumor Necrosis Factor Receptor Superfamily, Member 9/analysis; Tumor Necrosis Factor-alpha/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / Immunosuppression Therapy / CD8-Positive T-Lymphocytes / Influenza, Human / Tumor Necrosis Factor Receptor Superfamily, Member 9 / Lymphocytic Choriomeningitis Limits: Animals / Humans Language: En Journal: J Clin Invest Year: 2007 Document type: Article Affiliation country: United States Country of publication: United States

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