A-366833: a novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane alpha4beta2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models.

Ji, Jianguo; Bunnelle, William H; Anderson, David J; Faltynek, Connie; Dyhring, Tino; Ahring, Philip K; Rueter, Lynne E; Curzon, Peter; Buckley, Michael J; Marsh, Kennan C; Kempf-Grote, Anita; Meyer, Michael D

Ji, Jianguo; Bunnelle, William H; Anderson, David J; Faltynek, Connie; Dyhring, Tino; Ahring, Philip K; Rueter, Lynne E; Curzon, Peter; Buckley, Michael J; Marsh, Kennan C; Kempf-Grote, Anita; Meyer, Michael D.

Affiliation

Ji J; Neuroscience Research, Department-R47W, Bldg-AP9A, Global Pharmaceutical Research and Development, Abbott, Abbott Park, IL 60064, USA. jianguo.ji@abbott.com

Biochem Pharmacol ; 74(8): 1253-62, 2007 Oct 15.

Article in En | MEDLINE | ID: mdl-17854775

Subject(s)

Analgesics/pharmacology; Nicotinic Agonists/pharmacology; Receptors, Nicotinic/drug effects; Animals; Cystine/metabolism; Ferrets; Male; Mice; Models, Animal; Nausea/chemically induced; Nicotinic Agonists/chemical synthesis; Nicotinic Agonists/pharmacokinetics; Nicotinic Agonists/toxicity; Rats; Rats, Sprague-Dawley

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Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Nicotinic / Nicotinic Agonists / Analgesics Limits: Animals Language: En Journal: Biochem Pharmacol Year: 2007 Document type: Article Affiliation country: United States

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