[Pharmacokinetics of controlled-release oxycodone in patients with cancer pain].
Gan To Kagaku Ryoho
; 34(9): 1449-53, 2007 Sep.
Article
in Ja
| MEDLINE
| ID: mdl-17876144
ABSTRACT
Oxycodone is a useful analgesic for cancer patients in pain. However, its pharmacokinetics have not been sufficiently examined and there is a lack of information, with very few reports on pharmacokinetics concerning the absorption process in particular. With this in mind, we studied the pharmacokinetics of controlled-release oxycodone (Oxy contin). We measured its serum concentration in patients with cancer pain, and calculated parameters derived using the nonlinear least-squared method program (MULTI). In the result, pharmacokinetic parameters calculated at CL/F were 45.6+/-22.0 L/hr (Mean+/-SD), Vd/F 473.0+/-19 6.7 L, t(1/2) 7.2+/- 6.2 hr, kel 0.103+/-0.034, kal 1.082+/-0.604, Lag time 0.9 9+/-0.40 hr. In addition, the serum oxycodone concentration hardly rose until 1 hour after and just before medication, whereupon a rapid increase was evident after 1 hour. The pharmacokinetics of controlled-release oxycodone in patients with cancer pain were clarified in this study. Especially during the absorption process, the lag time was calculated specifically at about 1 hour, making it approximately equal to MS contin.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxycodone
/
Pain
/
Analgesics, Opioid
/
Neoplasms
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
Ja
Journal:
Gan To Kagaku Ryoho
Year:
2007
Document type:
Article