Preparation of tetrahydroimidazo[2,1-a]isoquinolines and their use as inhibitors of gastric acid secretion.
Bioorg Med Chem
; 15(24): 7647-60, 2007 Dec 15.
Article
in En
| MEDLINE
| ID: mdl-17881235
ABSTRACT
A series of novel tetrahydroimidazo[2,1-a]isoquinolines was prepared based on a hetero Diels-Alder reaction between an enamine and 1,2,4-triazine as key step. A structure-activity relationship was established focussing on the influence of the substitution pattern in position 3 and 6 of the heterocycle on antisecretory activity, lipophilicity, and pK(a) value. Potent inhibitors of the gastric acid pump were identified.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gastrointestinal Agents
/
Proton Pump Inhibitors
/
Gastric Acid
/
Isoquinolines
Language:
En
Journal:
Bioorg Med Chem
Journal subject:
BIOQUIMICA
/
QUIMICA
Year:
2007
Document type:
Article
Affiliation country:
Germany