Online gamma-camera imaging of 103Pd seeds (OGIPS) for permanent breast seed implantation.
Phys Med Biol
; 52(19): 5921-32, 2007 Oct 07.
Article
in En
| MEDLINE
| ID: mdl-17881809
ABSTRACT
Permanent brachytherapy seed implantation is being investigated as a mode of accelerated partial breast irradiation for early stage breast cancer patients. Currently, the seeds are poorly visualized during the procedure making it difficult to perform a real-time correction of the implantation if required. The objective was to determine if a customized gamma-camera can accurately localize the seeds during implantation. Monte Carlo simulations of a CZT based gamma-camera were used to assess whether images of suitable quality could be derived by detecting the 21 keV photons emitted from 74 MBq (103)Pd brachytherapy seeds. A hexagonal parallel hole collimator with a hole length of 38 mm, hole diameter of 1.2 mm and 0.2 mm septa, was modeled. The design of the gamma-camera was evaluated on a realistic model of the breast and three layers of the seed distribution (55 seeds) based on a pre-implantation CT treatment plan. The Monte Carlo simulations showed that the gamma-camera was able to localize the seeds with a maximum error of 2.0 mm, using only two views and 20 s of imaging. A gamma-camera can potentially be used as an intra-procedural image guidance system for quality assurance for permanent breast seed implantation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Palladium
/
Radioisotopes
/
Brachytherapy
/
Breast Neoplasms
/
Radionuclide Imaging
/
Prosthesis Implantation
Type of study:
Evaluation_studies
/
Guideline
/
Health_economic_evaluation
Limits:
Female
/
Humans
Language:
En
Journal:
Phys Med Biol
Year:
2007
Document type:
Article
Affiliation country:
Canada