Acute-myeloid-leukemia-targeted toxins kill tumor cells by cell-type-specific mechanisms and synergize with TRAIL to allow manipulation of the extent and mechanism of tumor cell death.

Horita, H; Frankel, A E; Thorburn, A

Horita, H; Frankel, A E; Thorburn, A.

Leukemia ; 22(3): 652-5, 2008 Mar.

Article in En | MEDLINE | ID: mdl-17882279

Subject(s)

Antineoplastic Agents/pharmacology; Diphtheria Toxin/pharmacology; Interleukin-3/pharmacology; Leukemia, Myeloid/drug therapy; Recombinant Fusion Proteins/pharmacology; Acute Disease; Amino Acid Chloromethyl Ketones/pharmacology; Antineoplastic Agents/toxicity; Apoptosis/drug effects; Benzamides/antagonists & inhibitors; Caspases/physiology; Cell Death/drug effects; Cell Line, Tumor/drug effects; Diphtheria Toxin/toxicity; Drug Delivery Systems; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Drug Synergism; Enzyme Activation/drug effects; Humans; Interleukin-3/toxicity; Leukemia, Myeloid/pathology; Neoplasm Proteins/drug effects; Neoplasm Proteins/physiology; Pyridines/antagonists & inhibitors; Receptors, Granulocyte-Macrophage Colony-Stimulating Factor/drug effects; Receptors, Interleukin-3/drug effects; Recombinant Fusion Proteins/toxicity; TNF-Related Apoptosis-Inducing Ligand/pharmacology; U937 Cells/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Recombinant Fusion Proteins / Leukemia, Myeloid / Interleukin-3 / Diphtheria Toxin / Antineoplastic Agents Limits: Humans Language: En Journal: Leukemia Journal subject: HEMATOLOGIA / NEOPLASIAS Year: 2008 Document type: Article

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