Disruption of type 5 adenylyl cyclase enhances desensitization of cyclic adenosine monophosphate signal and increases Akt signal with chronic catecholamine stress.

Okumura, Satoshi; Vatner, Dorothy E; Kurotani, Reiko; Bai, Yunzhe; Gao, Shumin; Yuan, Zengrong; Iwatsubo, Kousaku; Ulucan, Coskun; Kawabe, Jun-ichi; Ghosh, Kaushik; Vatner, Stephen F; Ishikawa, Yoshihiro

Okumura, Satoshi; Vatner, Dorothy E; Kurotani, Reiko; Bai, Yunzhe; Gao, Shumin; Yuan, Zengrong; Iwatsubo, Kousaku; Ulucan, Coskun; Kawabe, Jun-ichi; Ghosh, Kaushik; Vatner, Stephen F; Ishikawa, Yoshihiro.

Affiliation

Okumura S; Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan.

Circulation ; 116(16): 1776-83, 2007 Oct 16.

Article in En | MEDLINE | ID: mdl-17893275

Subject(s)

Adenosine Monophosphate/metabolism; Adenylyl Cyclases/genetics; Adenylyl Cyclases/metabolism; Catecholamines/metabolism; Heart Failure/metabolism; Isoenzymes/genetics; Isoenzymes/metabolism; Signal Transduction/physiology; Stress, Physiological/metabolism; Adrenergic beta-Agonists/pharmacology; Animals; Apoptosis/drug effects; Chronic Disease; Down-Regulation/physiology; G-Protein-Coupled Receptor Kinase 2/metabolism; Heart Failure/chemically induced; Heart Failure/physiopathology; Isoproterenol/pharmacology; Male; Mice; Mice, Knockout; Myocytes, Cardiac/cytology; Myocytes, Cardiac/drug effects; Proto-Oncogene Proteins c-akt/metabolism; Proto-Oncogene Proteins c-bcl-2/metabolism; Signal Transduction/drug effects; Stress, Physiological/chemically induced; Stress, Physiological/physiopathology

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Collection: 01-internacional Database: MEDLINE Main subject: Stress, Physiological / Signal Transduction / Catecholamines / Adenosine Monophosphate / Adenylyl Cyclases / Heart Failure / Isoenzymes Limits: Animals Language: En Journal: Circulation Year: 2007 Document type: Article Affiliation country: Japan Country of publication: United States

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