Facile preparation of new 4-phenylamino-3-quinolinecarbonitrile Src kinase inhibitors via 7-fluoro intermediates: identification of potent 7-amino analogs.

Boschelli, Diane H; Wu, Biqi; Ye, Fei; Durutlic, Haris; Golas, Jennifer M; Lucas, Judy; Boschelli, Frank

Boschelli, Diane H; Wu, Biqi; Ye, Fei; Durutlic, Haris; Golas, Jennifer M; Lucas, Judy; Boschelli, Frank.

Affiliation

Boschelli DH; Chemical and Screening Sciences, Wyeth Research, 401 N. Middletown Road, Pearl River, NY 10965, USA. bosched@wyeth.com

Bioorg Med Chem ; 16(1): 405-12, 2008 Jan 01.

Article in En | MEDLINE | ID: mdl-17905586

Subject(s)

Nitriles/chemical synthesis; Protein Kinase Inhibitors/chemical synthesis; Quinolines/chemical synthesis; src-Family Kinases/antagonists & inhibitors; Amines; Animals; Cell Line; Cell Proliferation/drug effects; Humans; Inhibitory Concentration 50; Nitriles/pharmacology; Protein Kinase Inhibitors/pharmacology; Quinolines/pharmacology; Rats; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / Src-Family Kinases / Protein Kinase Inhibitors / Nitriles Type of study: Diagnostic_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Document type: Article Affiliation country: United States Country of publication: United kingdom

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