Haloperidol protects striatal neurons from dysfunction induced by mutated huntingtin in vivo.

Charvin, Delphine; Roze, Emmanuel; Perrin, Valérie; Deyts, Carole; Betuing, Sandrine; Pagès, Christiane; Régulier, Etienne; Luthi-Carter, Ruth; Brouillet, Emmanuel; Déglon, Nicole; Caboche, Jocelyne

Charvin, Delphine; Roze, Emmanuel; Perrin, Valérie; Deyts, Carole; Betuing, Sandrine; Pagès, Christiane; Régulier, Etienne; Luthi-Carter, Ruth; Brouillet, Emmanuel; Déglon, Nicole; Caboche, Jocelyne.

Affiliation

Charvin D; Signalisation Neuronale et Régulations Géniques, Centre National de la Recherche Scientifique, Université Pierre et Marie Curie, UMR 7102, 9 quai Saint Bernard, 75005 Paris, France.

Neurobiol Dis ; 29(1): 22-9, 2008 Jan.

Article in En | MEDLINE | ID: mdl-17905594

Subject(s)

Antipsychotic Agents/therapeutic use; Corpus Striatum/pathology; Haloperidol/analogs & derivatives; Huntington Disease/prevention & control; Mutation/physiology; Nerve Tissue Proteins/genetics; Neurons/drug effects; Nuclear Proteins/genetics; Age Factors; Animals; Cell Count/methods; Corpus Striatum/metabolism; Disease Models, Animal; Dopamine and cAMP-Regulated Phosphoprotein 32/metabolism; Female; Gene Expression Regulation/drug effects; Haloperidol/therapeutic use; Huntingtin Protein; Huntington Disease/genetics; Huntington Disease/pathology; Lentivirus/physiology; Phosphopyruvate Hydratase/metabolism; Rats; Rats, Wistar

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Collection: 01-internacional Database: MEDLINE Main subject: Antipsychotic Agents / Nuclear Proteins / Huntington Disease / Corpus Striatum / Haloperidol / Mutation / Nerve Tissue Proteins / Neurons Type of study: Prognostic_studies Limits: Animals Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2008 Document type: Article Affiliation country: France Country of publication: United States

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