Peroxynitrite inactivation of human cytochrome P450s 2B6 and 2E1: heme modification and site-specific nitrotyrosine formation.

Lin, Hsia-Lien; Myshkin, Eugene; Waskell, Lucy; Hollenberg, Paul F

Lin, Hsia-Lien; Myshkin, Eugene; Waskell, Lucy; Hollenberg, Paul F.

Affiliation

Lin HL; Department of Pharmacology, University of Michigan and VA Medical Center, Ann Arbor, Michigan 48109, USA .

Chem Res Toxicol ; 20(11): 1612-22, 2007 Nov.

Article in En | MEDLINE | ID: mdl-17907788

Subject(s)

Aryl Hydrocarbon Hydroxylases/antagonists & inhibitors; Cytochrome P-450 CYP2E1 Inhibitors; Enzyme Inhibitors/pharmacology; Heme/chemistry; Oxidoreductases, N-Demethylating/antagonists & inhibitors; Peroxynitrous Acid/pharmacology; Tyrosine/analogs & derivatives; Amino Acid Sequence; Aryl Hydrocarbon Hydroxylases/chemistry; Aryl Hydrocarbon Hydroxylases/metabolism; Carbon Monoxide/chemistry; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2E1/chemistry; Cytochrome P-450 CYP2E1/metabolism; Humans; Models, Molecular; Molecular Sequence Data; Oxidoreductases, N-Demethylating/chemistry; Oxidoreductases, N-Demethylating/metabolism; Tyrosine/biosynthesis; tert-Butylhydroperoxide/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Oxidoreductases, N-Demethylating / Tyrosine / Aryl Hydrocarbon Hydroxylases / Peroxynitrous Acid / Enzyme Inhibitors / Cytochrome P-450 CYP2E1 Inhibitors / Heme Limits: Humans Language: En Journal: Chem Res Toxicol Journal subject: TOXICOLOGIA Year: 2007 Document type: Article Affiliation country: United States Country of publication: United States

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