Carrier-mediated transport of the quaternary ammonium neuronal nicotinic receptor antagonist n,n'-dodecylbispicolinium dibromide at the blood-brain barrier.

Lockman, Paul R; Manda, Vamshi K; Geldenhuys, Werner J; Mittapalli, Rajendar K; Thomas, Fancy; Albayati, Zaineb Fadhel; Crooks, Peter A; Dwoskin, Linda P; Allen, David D

Lockman, Paul R; Manda, Vamshi K; Geldenhuys, Werner J; Mittapalli, Rajendar K; Thomas, Fancy; Albayati, Zaineb Fadhel; Crooks, Peter A; Dwoskin, Linda P; Allen, David D.

Affiliation

Lockman PR; Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, 1300 S. Coulter Dr., Amarillo, TX 79106-1712, USA. paul.lockman@ttuhsc.edu

J Pharmacol Exp Ther ; 324(1): 244-50, 2008 Jan.

Article in En | MEDLINE | ID: mdl-17921191

Subject(s)

Blood-Brain Barrier/metabolism; Nerve Tissue Proteins/metabolism; Nicotinic Antagonists/metabolism; Picolines/metabolism; Plasma Membrane Neurotransmitter Transport Proteins/metabolism; Receptors, Nicotinic/metabolism; Animals; Choline/metabolism; Male; Rats; Rats, Inbred F344

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Collection: 01-internacional Database: MEDLINE Main subject: Picolines / Blood-Brain Barrier / Receptors, Nicotinic / Nicotinic Antagonists / Plasma Membrane Neurotransmitter Transport Proteins / Nerve Tissue Proteins Limits: Animals Language: En Journal: J Pharmacol Exp Ther Year: 2008 Document type: Article Affiliation country: United States

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