Changes in the plasma diazepam concentration and its anticonvulsant effect after the discharge of a diazepam suppository from the rectum in rats.

Hidaka, N; Suemaru, K; Araki, H

Hidaka, N; Suemaru, K; Araki, H.

Affiliation

Hidaka N; Division of Pharmacy, Ehime University Hospital, Shitsukawa, Toon, Ehime, Japan.

Methods Find Exp Clin Pharmacol ; 29(6): 401-4, 2007.

Article in En | MEDLINE | ID: mdl-17922068

Subject(s)

Anticonvulsants/blood; Anticonvulsants/therapeutic use; Diazepam/blood; Diazepam/therapeutic use; Seizures/prevention & control; Analysis of Variance; Animals; Anticonvulsants/administration & dosage; Biological Availability; Diazepam/administration & dosage; Dose-Response Relationship, Drug; Intestinal Absorption; Male; Pentylenetetrazole; Rats; Rats, Sprague-Dawley; Rectum; Seizures/chemically induced; Suppositories; Time Factors

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Collection: 01-internacional Database: MEDLINE Main subject: Seizures / Diazepam / Anticonvulsants Limits: Animals Language: En Journal: Methods Find Exp Clin Pharmacol Year: 2007 Document type: Article Affiliation country: Japan Country of publication: Spain

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