[Surgical management and outcomes of lung cancer in women - results from the Epithor database]. / Particularités de la prise en charge chirurgicale du cancer bronchique chez la femme. Données de la base nationale Epithor.
Rev Mal Respir
; 24(7): 877-82, 2007 Sep.
Article
in Fr
| MEDLINE
| ID: mdl-17925670
ABSTRACT
INTRODUCTION:
Rates of lung cancer in women have been increasing continually for several years. The basic surgical management of this condition is the same in both sexes but a number of differences are apparent.METHODS:
We analysed data entered onto the Epithor database between June 2002 and June 2006 concerning 8535 surgical resections performed in primary lung cancer.RESULTS:
22.5 percent of patients were women. They were significantly younger (59.6 years vs 62.7 years) and had a lower BMI (24.7 kg x m(-2) vs 25.5 kg x m(-2)). They were in a better physical condition in terms of American Society of Anaesthesiology score and performance status, with better preserved lung function and fewer co-morbidities (1.8 vs 2.1) compared to men. The percentage of adenocarcinomas was higher in women and a higher proportion had early stage disease. 30 day mortality was three times as high in men who also experienced much greater post-operative morbidity. Multivariate analysis revealed an odds ratio of 0.49 (95% CI 0.3-0.8) for mortality and 0.54 (95% CI 0.4-0.6) for morbidity in women compared to men.CONCLUSION:
Women with lung cancer have less risk of post-operative morbidity and mortality than men. These data suggest that they might be able to benefit from more aggressive perioperative therapy.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Lung Neoplasms
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Europa
Language:
Fr
Journal:
Rev Mal Respir
Year:
2007
Document type:
Article
Affiliation country:
France