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Potent, orally bioavailable calcitonin gene-related peptide receptor antagonists for the treatment of migraine: discovery of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974).
Paone, Daniel V; Shaw, Anthony W; Nguyen, Diem N; Burgey, Christopher S; Deng, James Z; Kane, Stefanie A; Koblan, Kenneth S; Salvatore, Christopher A; Mosser, Scott D; Johnston, Victor K; Wong, Bradley K; Miller-Stein, Cynthia M; Hershey, James C; Graham, Samuel L; Vacca, Joseph P; Williams, Theresa M.
Affiliation
  • Paone DV; Department of Medicinal Chemistry, Merck Research Laboratories, P.O. Box 4, West Point, Pennsylvania 19486, USA. daniel_paone@merck.com
J Med Chem ; 50(23): 5564-7, 2007 Nov 15.
Article in En | MEDLINE | ID: mdl-17929795
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Collection: 01-internacional Database: MEDLINE Main subject: Azepines / Calcitonin Gene-Related Peptide Receptor Antagonists / Imidazoles / Migraine Disorders Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2007 Document type: Article Affiliation country: United States Country of publication: United States
Search on Google
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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Azepines / Calcitonin Gene-Related Peptide Receptor Antagonists / Imidazoles / Migraine Disorders Limits: Animals / Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 2007 Document type: Article Affiliation country: United States Country of publication: United States