ATF2 on the double - activating transcription factor and DNA damage response protein.
Pigment Cell Res
; 20(6): 498-506, 2007 Dec.
Article
in En
| MEDLINE
| ID: mdl-17935492
ABSTRACT
Signal transduction pathways play a key role in the regulation of key cellular processes, including survival and death. Growing evidence points to changes in signaling pathway that occur during skin tumor development and progression. Such changes impact the activity of downstream substrates, including transcription factors. The activating transcription factor 2 (ATF2) has been implicated in malignant and non-malignant skin tumor developments. ATF2 mediates both transcription and DNA damage control, through its phosphorylation by JNK/p38 or ATM/ATR respectively. Here, we summarize our present understanding of ATF2 regulation, function and contribution to malignant and non-malignant skin tumor development.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
DNA Damage
/
Activating Transcription Factor 2
Limits:
Animals
/
Humans
Language:
En
Journal:
Pigment Cell Res
Year:
2007
Document type:
Article
Affiliation country:
United States