Clinical features of patients with myasthenia gravis associated with autoimmune diseases.
Eur J Neurol
; 14(12): 1403-4, 2007 Dec.
Article
in En
| MEDLINE
| ID: mdl-17941854
We investigated the incidence and clinical features of patients with myasthenia gravis (MG) associated with autoimmune diseases. Associated autoimmune diseases were found in 28 of 142 consecutive Japanese MG patients (19.7%), amongst which Graves' disease (7.7%) and Hashimoto's thyroiditis (4.2%) were predominant. The clinical features of MG patients with Graves' disease were different from those of MG patients without autoimmune diseases in terms of age at onset of MG symptoms (35.5 +/- 4.0 years and 49.0 +/- 1.7 years; P < 0.05), positivity for the anti-acetylcholine receptor antibody (44.4% and 89.8%; P < 0.05), and association with thymic hyperplasia (72.7 and 17.9%; P < 0.05). The therapeutic outcome of MG patients with Graves' disease and that of those without autoimmune diseases were not significantly different. Further studies should be performed to investigate whether MG associated with Graves' disease is a distinct subtype of MG.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Autoimmune Diseases
/
Myasthenia Gravis
Type of study:
Prevalence_studies
/
Risk_factors_studies
Limits:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Child
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Eur J Neurol
Journal subject:
NEUROLOGIA
Year:
2007
Document type:
Article
Affiliation country:
Japan
Country of publication:
United kingdom