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Batracylin (NSC 320846), a dual inhibitor of DNA topoisomerases I and II induces histone gamma-H2AX as a biomarker of DNA damage.
Rao, V Ashutosh; Agama, Keli; Holbeck, Susan; Pommier, Yves.
Affiliation
  • Rao VA; Laboratory of Molecular Pharmacology and Developmental Therapeutics Program, National Cancer Institute, Department of Health and Human Services, Bethesda, Maryland 20892, USA.
Cancer Res ; 67(20): 9971-9, 2007 Oct 15.
Article in En | MEDLINE | ID: mdl-17942930
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Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / DNA Damage / Histones / Enzyme Inhibitors / Topoisomerase I Inhibitors / Topoisomerase II Inhibitors Limits: Humans Language: En Journal: Cancer Res Year: 2007 Document type: Article Affiliation country: United States Country of publication: United States
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Collection: 01-internacional Database: MEDLINE Main subject: Quinazolines / DNA Damage / Histones / Enzyme Inhibitors / Topoisomerase I Inhibitors / Topoisomerase II Inhibitors Limits: Humans Language: En Journal: Cancer Res Year: 2007 Document type: Article Affiliation country: United States Country of publication: United States