Exploring modular domino reactions: competing processes based on the nature of the angular substituent.
Org Lett
; 9(23): 4841-4, 2007 Nov 08.
Article
in En
| MEDLINE
| ID: mdl-17949098
ABSTRACT
The octaline diol system 6 was found to undergo an interesting set of reactions upon treatment with PhI(OAc)2, leading, in a single synthetic operation, to complex oxygen heterocycles. Experimental evidence supports an intramolecular hetero[4 + 2 + 2] adduct that has heretofore never been observed, which completely dominates the hetero[4 + 2] path in several cases. The domino protocol can be biased one way or another depending on both the nature of the pi-system and the length of the methylene spacer at the angular position.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Heterocyclic Compounds
Type of study:
Guideline
Language:
En
Journal:
Org Lett
Journal subject:
BIOQUIMICA
Year:
2007
Document type:
Article
Affiliation country:
France