Increasing the potency of a cytotoxin with an arginine graft.

Fuchs, Stephen M; Rutkoski, Thomas J; Kung, Vanessa M; Groeschl, Ryan T; Raines, Ronald T

Fuchs, Stephen M; Rutkoski, Thomas J; Kung, Vanessa M; Groeschl, Ryan T; Raines, Ronald T.

Affiliation

Fuchs SM; Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706-1544, USA.

Protein Eng Des Sel ; 20(10): 505-9, 2007 Oct.

Article in En | MEDLINE | ID: mdl-17954521

Subject(s)

Arginine/metabolism; Cytotoxins/chemistry; Cytotoxins/toxicity; Ribonuclease, Pancreatic/chemistry; Ribonuclease, Pancreatic/metabolism; Amino Acid Sequence; Amino Acids, Acidic/chemistry; Animals; Arginine/genetics; Binding Sites; Cations/chemistry; Cattle; Cell Line; Cytotoxins/genetics; Cytotoxins/metabolism; Databases, Protein; Humans; Intracellular Signaling Peptides and Proteins; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Permeability; Protein Structure, Quaternary; Proteins/chemistry; Recombinant Proteins; Ribonuclease, Pancreatic/antagonists & inhibitors; Ribonuclease, Pancreatic/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Arginine / Ribonuclease, Pancreatic / Cytotoxins Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Protein Eng Des Sel Journal subject: BIOQUIMICA / BIOTECNOLOGIA Year: 2007 Document type: Article Affiliation country: United States Country of publication: United kingdom

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