Production of P-glycoprotein from the MDR1 upstream promoter is insufficient to affect the response to first-line chemotherapy in advanced breast cancer.

Raguz, Selina; Randle, Rebecca A; Sharpe, Eva R; Foekens, John A; Sieuwerts, Anieta M; Meijer-van Gelder, Marion E; Melo, Junia V; Higgins, Christopher F; Yagüe, Ernesto

Raguz, Selina; Randle, Rebecca A; Sharpe, Eva R; Foekens, John A; Sieuwerts, Anieta M; Meijer-van Gelder, Marion E; Melo, Junia V; Higgins, Christopher F; Yagüe, Ernesto.

Affiliation

Raguz S; Medical Research Council Clinical Sciences Centre, Imperial College Faculty of Medicine, Hammersmith Hospital Campus, London, United Kingdom.

Int J Cancer ; 122(5): 1058-67, 2008 Mar 01.

Article in En | MEDLINE | ID: mdl-17955490

Subject(s)

ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics; Antineoplastic Agents/therapeutic use; Breast Neoplasms/drug therapy; Breast Neoplasms/genetics; Drug Resistance, Multiple/genetics; Promoter Regions, Genetic/genetics; Adult; Cloning, Molecular; Electrophoretic Mobility Shift Assay; Female; Genes, MDR; Humans; Middle Aged; RNA, Messenger/analysis; Reverse Transcriptase Polymerase Chain Reaction

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Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Promoter Regions, Genetic / ATP Binding Cassette Transporter, Subfamily B, Member 1 / Drug Resistance, Multiple / Antineoplastic Agents Type of study: Prognostic_studies Limits: Adult / Female / Humans / Middle aged Language: En Journal: Int J Cancer Year: 2008 Document type: Article Affiliation country: United kingdom

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