Urinary protein 1/Clara cell 16 concentrations and lung functions in male subjects with pneumoconiosis.
Ann Clin Biochem
; 44(Pt 6): 560-2, 2007 Nov.
Article
in En
| MEDLINE
| ID: mdl-17961312
ABSTRACT
BACKGROUND:
Protein 1 (P1)/Clara cell 16 kDa protein (CC16, previously named CC10), a potentially immunosuppressive protein secreted by non-ciliated cells of the tracheobronchial epithelium, has been found to be a new useful lung-specific biomarker in several pathological lung conditions. Particularly, urinary P1 (uP1) may reflect the altered lung functions in pneumoconiosis.METHODS:
We investigated the relationship between uP1 values and lung functions in 31 non-smoking pneumoconiotic males (mean age 73 years) with a history of dust exposure work in shipbuilding. The protein was measured using an originally prepared enzyme-linked immunosorbent assay system. The forced expiratory volume in 1 s % (FEV(1.0)%) and % vital capacity (%VC) were tested with a spirometer.RESULTS:
The mean values of uP1 were 4.62 +/- 4.82 (mean +/- standard deviation) ng/mol creatinine. A univariable correlation test showed a significant positive correlation between uP1 and %VC (r = 0.356, P = 0.049). Also, a multiple regression analysis, when adjusted for age, disease duration, FEV(1.0)% and %VC, showed a significant correlation of uP1 with %VC (beta = 0.467, P = 0.030).CONCLUSION:
The results suggest that a decreased uP1, corroborated by a decreased %VC, may be the result of damage to secretory cells. Measurement of uP1 may become a possible index of fibrotic changes in pneumoconiosis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pneumoconiosis
/
Uteroglobin
/
Lung
Type of study:
Etiology_studies
/
Evaluation_studies
Limits:
Aged
/
Aged80
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Ann Clin Biochem
Year:
2007
Document type:
Article
Affiliation country:
Japan