[Response of antileptospira IgG antibodies in individuals immunized with vax-SPIRAL]. / Respuesta de anticuerpos IgG antileptospira en individuos inmunizados con vax-SPIRAL.
Rev Cubana Med Trop
; 57(1): 32-7, 2005.
Article
in Es
| MEDLINE
| ID: mdl-17966473
ABSTRACT
A quantitative ELISA for the detection of IgG antibodies in response to the Cuban vaccine against the human leptospirosis (vax-SPIRAL) was applied to 930 volunteers'sera, 483 immunized with vax-SPIRAL and 447 with a vaccine against hepatitis B. Samples were taken before beginning the study, 21 days after the second dose and a year later. A high seroprevalence of antibodies to the vaccine serovars was observed before beginning the study. The initial value of the response doubled at 21 days of the second dose in 45 % of the individuals. There were markedly significant differences (p=0,000000) between both groups. A similar response to the three leptospiral serovars was found. After the year the levels of antibodies decreased; however, 23.1% of the individuals were able to duplicate their level of antibodies regarding the initial moment, and the significant difference with the group that received the vaccine against hepatitis B still existed. The application of this Cuban immunogen amomg the main risk groups was recommended.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Immunoglobulin G
/
Enzyme-Linked Immunosorbent Assay
/
Bacterial Vaccines
/
Leptospira interrogans
/
Leptospirosis
/
Antibodies, Bacterial
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Country/Region as subject:
Caribe
/
Cuba
Language:
Es
Journal:
Rev Cubana Med Trop
Year:
2005
Document type:
Article