[Clinical study of trimetazidine for myocardial protection in acute myocardial infarction].
Zhonghua Nei Ke Za Zhi
; 46(8): 633-6, 2007 Aug.
Article
in Zh
| MEDLINE
| ID: mdl-17967230
ABSTRACT
OBJECTIVE:
To assess the effect of trimetazidine as an adjunctive treatment to reperfusion therapy in acute myocardial infarction.METHODS:
Sixty patients with acute myocardial infarction were randomized to receive trimetazidine (a loading dose of 60 mg followed by 20 mg 3 times daily) for 2 weeks (n = 32) or to be controls (n = 28). The loading dose was started early before the reperfusion therapy. Patients received intermittent ST-segment monitoring to assess the resolution of ST-segment deviation one hour after reperfusion therapy. Venous blood samples for measurement of malondialdehyde (MDA) and endothelin (ET-1) were taken immediately on admission and 1, 4, 8, 24 and 48 hours as well as 7 days after reperfusion. In-hospital and 3-months major adverse cardiac events were recorded.RESULTS:
Blinded ST-segment analysis showed that there was a more marked return towards baseline one hour after reperfusion therapy in the trimetazidine group, than in the control group [change (7.14 +/- 3.50) mm vs (3.79 +/- 1.32) mm, P = 0.041]. The measurement of plasma MDA showed that, there was a significantly lower level in the trimetazidine group 4, 8, 24, 48 hours and 7 days after reperfusion (P < 0.05). The level of plasma ET-1 was significantly lower in the trimetazidine group 8 hours and 7 days after reperfusion (P < 0.05). There was no side effect due to trimetazidine. Clinical outcomes were similar between the two groups.CONCLUSIONS:
Trimetazidine is effective for the resolution of ST-segment elevation. The effect of trimetazidine against malondialdehyde and ET-1 formation suggested that it might be the mechanism of the myocardial protection.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Trimetazidine
/
Myocardial Infarction
Type of study:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
Limits:
Aged
/
Humans
/
Male
/
Middle aged
Language:
Zh
Journal:
Zhonghua Nei Ke Za Zhi
Year:
2007
Document type:
Article
Affiliation country:
China
Publication country:
CHINA
/
CN
/
REPUBLIC OF CHINA