PTP1B contributes to the oncogenic properties of colon cancer cells through Src activation.

Zhu, Shudong; Bjorge, Jeffrey D; Fujita, Donald J

Zhu, Shudong; Bjorge, Jeffrey D; Fujita, Donald J.

Affiliation

Zhu S; Department of Biochemistry and Molecular Biology, and Southern Alberta Cancer Research Institute, University of Calgary, Calgary, Alberta, Canada.

Cancer Res ; 67(21): 10129-37, 2007 Nov 01.

Article in En | MEDLINE | ID: mdl-17974954

Subject(s)

Colonic Neoplasms/etiology; Protein Tyrosine Phosphatase, Non-Receptor Type 1/physiology; src-Family Kinases/metabolism; Animals; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms/enzymology; Colonic Neoplasms/pathology; Enzyme Activation; Humans; Male; Mice; Mice, SCID; Phosphorylation; Protein Tyrosine Phosphatase, Non-Receptor Type 1/antagonists & inhibitors; Protein Tyrosine Phosphatase, Non-Receptor Type 1/genetics; Proto-Oncogene Proteins c-fyn/metabolism; RNA, Small Interfering/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Colonic Neoplasms / Src-Family Kinases / Protein Tyrosine Phosphatase, Non-Receptor Type 1 Limits: Animals / Humans / Male Language: En Journal: Cancer Res Year: 2007 Document type: Article Affiliation country: Canada

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