Design and synthesis of a functionally selective D3 agonist and its in vivo delivery via the intranasal route.

Blagg, Julian; Allerton, Charlotte M N; Batchelor, David V J; Baxter, Andrew D; Burring, Denise J; Carr, Christopher L; Cook, Andrew S; Nichols, Carly L; Phipps, Joanne; Sanderson, Vivienne G; Verrier, Hugh; Wong, Stephen

Blagg, Julian; Allerton, Charlotte M N; Batchelor, David V J; Baxter, Andrew D; Burring, Denise J; Carr, Christopher L; Cook, Andrew S; Nichols, Carly L; Phipps, Joanne; Sanderson, Vivienne G; Verrier, Hugh; Wong, Stephen.

Affiliation

Blagg J; Pfizer Global Research & Development, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK.

Bioorg Med Chem Lett ; 17(24): 6691-6, 2007 Dec 15.

Article in En | MEDLINE | ID: mdl-17976986

Subject(s)

Dopamine Agonists/administration & dosage; Dopamine Agonists/chemical synthesis; Drug Design; Receptors, Dopamine D3/agonists; Administration, Intranasal; Animals; Crystallography, X-Ray; Dogs; Dopamine Agonists/chemistry; Dopamine Agonists/pharmacokinetics; Humans; Models, Molecular; Molecular Structure; Rats; Receptors, Dopamine D3/metabolism; Stereoisomerism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Drug Design / Dopamine Agonists / Receptors, Dopamine D3 Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2007 Document type: Article Affiliation country: United kingdom Country of publication: United kingdom

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