Blocking of IL-6 signaling pathway prevents CD4+ T cell-mediated colitis in a T(h)17-independent manner.

Noguchi, Daisuke; Wakita, Daiko; Tajima, Masaki; Ashino, Shigeru; Iwakura, Yoichiro; Zhang, Yue; Chamoto, Kenji; Kitamura, Hidemitsu; Nishimura, Takashi

Noguchi, Daisuke; Wakita, Daiko; Tajima, Masaki; Ashino, Shigeru; Iwakura, Yoichiro; Zhang, Yue; Chamoto, Kenji; Kitamura, Hidemitsu; Nishimura, Takashi.

Affiliation

Noguchi D; Division of Immunoregulation Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan.

Int Immunol ; 19(12): 1431-40, 2007 Dec.

Article in En | MEDLINE | ID: mdl-17981790

Subject(s)

CD4-Positive T-Lymphocytes/immunology; Colitis/immunology; Interleukin-10/metabolism; Interleukin-6/metabolism; Receptors, Interleukin-6/metabolism; T-Lymphocyte Subsets/immunology; Animals; Colon/immunology; Immunologic Memory; Interferon-gamma/immunology; Interferon-gamma/metabolism; Interleukin-10/immunology; Interleukin-17/immunology; Interleukin-17/metabolism; Interleukin-4/immunology; Interleukin-4/metabolism; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Receptors, Interleukin-6/immunology; Signal Transduction; T-Lymphocytes, Regulatory/immunology

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Collection: 01-internacional Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / T-Lymphocyte Subsets / Interleukin-6 / Interleukin-10 / Colitis / Receptors, Interleukin-6 Limits: Animals Language: En Journal: Int Immunol Journal subject: ALERGIA E IMUNOLOGIA Year: 2007 Document type: Article Affiliation country: Japan

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