Substituted 2-oxo-azepane derivatives are potent, orally active gamma-secretase inhibitors.

Kitas, Eric A; Galley, Guido; Jakob-Roetne, Roland; Flohr, Alexander; Wostl, Wolfgang; Mauser, Harald; Alker, André M; Czech, Christian; Ozmen, Laurence; David-Pierson, Pascale; Reinhardt, Dieter; Jacobsen, Helmut

Kitas, Eric A; Galley, Guido; Jakob-Roetne, Roland; Flohr, Alexander; Wostl, Wolfgang; Mauser, Harald; Alker, André M; Czech, Christian; Ozmen, Laurence; David-Pierson, Pascale; Reinhardt, Dieter; Jacobsen, Helmut.

Affiliation

Kitas EA; Pharma Division, Discovery Chemistry, F. Hoffmann-La Roche Ltd, CH-4070 Basel, Switzerland. eric_a.kitas@roche.com

Bioorg Med Chem Lett ; 18(1): 304-8, 2008 Jan 01.

Article in En | MEDLINE | ID: mdl-17983746

Subject(s)

Amyloid Precursor Protein Secretases/antagonists & inhibitors; Azepines/chemistry; Azepines/pharmacology; Protease Inhibitors/chemistry; Protease Inhibitors/pharmacology; Animals; Azepines/chemical synthesis; Humans; Hydroxamic Acids/chemistry; Mice; Mice, Transgenic; Models, Molecular; Protease Inhibitors/chemical synthesis; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Protease Inhibitors / Azepines / Amyloid Precursor Protein Secretases Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2008 Document type: Article Affiliation country: Switzerland Country of publication: United kingdom

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