DMBT1 confers mucosal protection in vivo and a deletion variant is associated with Crohn's disease.

Renner, Marcus; Bergmann, Gaby; Krebs, Inge; End, Caroline; Lyer, Stefan; Hilberg, Frank; Helmke, Burkhard; Gassler, Nikolaus; Autschbach, Frank; Bikker, Floris; Strobel-Freidekind, Olga; Gronert-Sum, Sabine; Benner, Axel; Blaich, Stephanie; Wittig, Rainer; Hudler, Melanie; Ligtenberg, Antoon J; Madsen, Jens; Holmskov, Uffe; Annese, Vito; Latiano, Anna; Schirmacher, Peter; Amerongen, Arie V Nieuw; D'Amato, Mauro; Kioschis, Petra; Hafner, Mathias; Poustka, Annemarie; Mollenhauer, Jan

Renner, Marcus; Bergmann, Gaby; Krebs, Inge; End, Caroline; Lyer, Stefan; Hilberg, Frank; Helmke, Burkhard; Gassler, Nikolaus; Autschbach, Frank; Bikker, Floris; Strobel-Freidekind, Olga; Gronert-Sum, Sabine; Benner, Axel; Blaich, Stephanie; Wittig, Rainer; Hudler, Melanie; Ligtenberg, Antoon J; Madsen, Jens; Holmskov, Uffe; Annese, Vito; Latiano, Anna; Schirmacher, Peter; Amerongen, Arie V Nieuw; D'Amato, Mauro; Kioschis, Petra; Hafner, Mathias; Poustka, Annemarie; Mollenhauer, Jan.

Affiliation

Renner M; Division of Molecular Genome Analysis, Deutsches Krebsforschungszentrum, Heidelberg, Germany.

Gastroenterology ; 133(5): 1499-509, 2007 Nov.

Article in En | MEDLINE | ID: mdl-17983803

Subject(s)

Crohn Disease/genetics; Crohn Disease/physiopathology; Gene Deletion; Intestinal Mucosa/physiopathology; Receptors, Cell Surface/genetics; Receptors, Cell Surface/physiology; Adolescent; Adult; Aged; Aged, 80 and over; Animals; Calcium-Binding Proteins; Case-Control Studies; Child; Crohn Disease/chemically induced; DNA-Binding Proteins; Dextran Sulfate; Disease Susceptibility; Exons/genetics; Female; Humans; Interleukin-6/metabolism; Intestinal Mucosa/metabolism; Intestinal Mucosa/pathology; Male; Mice; Mice, Transgenic; Middle Aged; Mucins/genetics; Mucins/physiology; Nod2 Signaling Adaptor Protein/metabolism; RNA, Messenger/metabolism; Risk Factors; Tumor Necrosis Factor-alpha/metabolism; Tumor Suppressor Proteins; Up-Regulation/genetics

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Collection: 01-internacional Database: MEDLINE Main subject: Crohn Disease / Gene Deletion / Receptors, Cell Surface / Intestinal Mucosa Type of study: Etiology_studies / Observational_studies / Risk_factors_studies Limits: Adolescent / Adult / Aged / Aged80 / Animals / Child / Female / Humans / Male / Middle aged Language: En Journal: Gastroenterology Year: 2007 Document type: Article Affiliation country: Germany Country of publication: United States

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