The SH3 domain of Lck modulates T-cell receptor-dependent activation of extracellular signal-regulated kinase through activation of Raf-1.

Li, Manqing; Ong, Su Sien; Rajwa, Bartek; Thieu, Vivian T; Geahlen, Robert L; Harrison, Marietta L

Li, Manqing; Ong, Su Sien; Rajwa, Bartek; Thieu, Vivian T; Geahlen, Robert L; Harrison, Marietta L.

Affiliation

Li M; Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, Hansen Life Sciences Building, 201 South University Street, West Lafayette, IN 47907, USA.

Mol Cell Biol ; 28(2): 630-41, 2008 Jan.

Article in En | MEDLINE | ID: mdl-17998336

Subject(s)

Extracellular Signal-Regulated MAP Kinases/metabolism; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/metabolism; MAP Kinase Signaling System; Proto-Oncogene Proteins c-raf/metabolism; Receptors, Antigen, T-Cell/metabolism; CD3 Complex/metabolism; Enzyme Activation; Gene Expression Regulation, Enzymologic; Golgi Apparatus/metabolism; Humans; Jurkat Cells; Lymphocyte Specific Protein Tyrosine Kinase p56(lck)/genetics; Mitogen-Activated Protein Kinase Kinases/metabolism; Phospholipase C gamma/metabolism; Phosphorylation; Phosphoserine/metabolism; Phosphotyrosine/metabolism; Protein Transport; Proto-Oncogene Proteins c-raf/genetics; Substrate Specificity; ZAP-70 Protein-Tyrosine Kinase/metabolism; src Homology Domains

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Antigen, T-Cell / Proto-Oncogene Proteins c-raf / Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / MAP Kinase Signaling System / Extracellular Signal-Regulated MAP Kinases Limits: Humans Language: En Journal: Mol Cell Biol Year: 2008 Document type: Article Affiliation country: United States

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