Operative indications for lung cancer with idiopathic pulmonary fibrosis.
Thorac Cardiovasc Surg
; 55(8): 505-8, 2007 Dec.
Article
in En
| MEDLINE
| ID: mdl-18027337
ABSTRACT
BACKGROUND:
Idiopathic pulmonary fibrosis (IPF) is well known to be associated with lung cancer. However, surgical morbidity and mortality in lung cancer patients with IPF remains unclear.METHODS:
The data of patients who underwent surgery for non-small cell lung cancer were retrospectively reviewed.RESULTS:
Of the 1063 patients with lung cancer, 33 (3.1 %) had IPF. Patients with IPF had significantly higher postoperative pulmonary morbidity and mortality than those without IPF (33.3 vs. 2.0 %; 18.2 vs. 1.3 %, respectively, P < 0.0001). Patients with IPF had a significantly higher incidence of postoperative acute lung injury/acute respiratory distress syndrome (ALI/ARDS) than those without IPF (27.3 vs. 1.3 %, P < 0.0001). IPF patients with postoperative ALI/ARDS had a significantly lower preoperative %FVC than those without postoperative ALI/ARDS (74 +/- 9 vs. 103 +/- 14 %, P < 0.0001).CONCLUSIONS:
Lung cancer patients with IPF who have a low preoperative %FVC should be carefully assessed prior to any surgical intervention.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pneumonectomy
/
Pulmonary Fibrosis
/
Decision Making
/
Lung Neoplasms
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Thorac Cardiovasc Surg
Year:
2007
Document type:
Article
Affiliation country:
Japan