4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG.

Strauss, G; Westhoff, M-A; Fischer-Posovszky, P; Fulda, S; Schanbacher, M; Eckhoff, S M; Stahnke, K; Vahsen, N; Kroemer, G; Debatin, K-M

Strauss, G; Westhoff, M-A; Fischer-Posovszky, P; Fulda, S; Schanbacher, M; Eckhoff, S M; Stahnke, K; Vahsen, N; Kroemer, G; Debatin, K-M.

Affiliation

Strauss G; University Children's Hospital, Ulm, Germany.

Cell Death Differ ; 15(2): 332-43, 2008 Feb.

Article in En | MEDLINE | ID: mdl-18034189

Subject(s)

Apoptosis Inducing Factor/metabolism; Apoptosis; Cell Nucleus/metabolism; Cyclophosphamide/analogs & derivatives; Endodeoxyribonucleases/metabolism; Oxidative Stress; T-Lymphocytes/drug effects; Acetylcysteine/pharmacology; Active Transport, Cell Nucleus; Animals; Caspases/metabolism; Cells, Cultured; Cyclophosphamide/pharmacology; Free Radical Scavengers/pharmacology; Humans; Immunosuppressive Agents/pharmacology; Jurkat Cells; Mice; Mice, Inbred BALB C; Mitochondria/metabolism; Proto-Oncogene Proteins c-bcl-2/metabolism; T-Lymphocytes/physiology; T-Lymphocytes, Cytotoxic/drug effects; T-Lymphocytes, Cytotoxic/physiology; Tumor Suppressor Protein p53/antagonists & inhibitors

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Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes / Cell Nucleus / Apoptosis / Oxidative Stress / Cyclophosphamide / Endodeoxyribonucleases / Apoptosis Inducing Factor Limits: Animals / Humans Language: En Journal: Cell Death Differ Year: 2008 Document type: Article Affiliation country: Germany Country of publication: United kingdom

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