An assessment of the onset and duration of action of olopatadine nasal spray.
Otolaryngol Head Neck Surg
; 137(6): 918-24, 2007 Dec.
Article
in En
| MEDLINE
| ID: mdl-18036421
ABSTRACT
OBJECTIVE:
Seasonal allergic rhinitis (SAR) is a highly prevalent disease. This study was conducted to evaluate the onset and duration of action of three concentrations of olopatadine nasal spray.METHODS:
This was a randomized, double-blind, single-dose, placebo-controlled study, conducted in an environmental exposure chamber in patients with SAR. A total of 320 patients were exposed to ragweed allergen in the chamber and randomized to olopatadine nasal spray 0.2%, 0.4%, 0.6%, or placebo nasal spray. Symptoms (sneezing, runny, itchy, and stuffy nose) were self-assessed during a 12-hour study period.RESULTS:
All concentrations of olopatadine nasal spray provided clinically meaningful reductions in total nasal symptom scores at 30 minutes compared to the placebo. Olopatadine nasal spray 0.6% was significantly more effective (P < 0.05) than placebo nasal spray at all time-points starting at 90 minutes post-dose and continuing over 12 hours.CONCLUSIONS:
Olopatadine nasal spray 0.6% demonstrated a fast onset of action and maintained an effect for at least 12 hours after dosing.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rhinitis, Allergic, Seasonal
/
Anti-Allergic Agents
/
Dibenzoxepins
Type of study:
Clinical_trials
Limits:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Otolaryngol Head Neck Surg
Year:
2007
Document type:
Article
Affiliation country:
Canada