In-vivo and in-vitro studies on the effect of Huang-Lian-Jie-Du-Tang on nimodipine transport across rat blood-brain barrier.

Zhang, Dong Mei; He, Zhen Wei; Liu, Xiao Dong; Li, Yang; Xie, Lin; Wang, Guang Ji; Liu, Li

Zhang, Dong Mei; He, Zhen Wei; Liu, Xiao Dong; Li, Yang; Xie, Lin; Wang, Guang Ji; Liu, Li.

Affiliation

Zhang DM; Center of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, 210009, China.

J Pharm Pharmacol ; 59(12): 1733-8, 2007 Dec.

Article in En | MEDLINE | ID: mdl-18053337

Subject(s)

Blood-Brain Barrier/metabolism; Drugs, Chinese Herbal/pharmacology; Nimodipine/pharmacokinetics; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism; Animals; Area Under Curve; Biological Transport/drug effects; Blotting, Western; Brain/blood supply; Brain/metabolism; Calcium Channel Blockers/metabolism; Calcium Channel Blockers/pharmacokinetics; Capillaries/cytology; Cells, Cultured; Endothelial Cells/cytology; Endothelial Cells/drug effects; Endothelial Cells/metabolism; Male; Metabolic Clearance Rate/drug effects; Nimodipine/blood; Nimodipine/metabolism; Plant Extracts/isolation & purification; Plant Extracts/pharmacology; Rats; Rats, Sprague-Dawley; Rhodamine 123/metabolism; Rhodamine 123/pharmacokinetics; Serum

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Collection: 01-internacional Database: MEDLINE Main subject: Drugs, Chinese Herbal / Blood-Brain Barrier / Nimodipine Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Pharm Pharmacol Year: 2007 Document type: Article Affiliation country: China

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