Lyn-coupled LacCer-enriched lipid rafts are required for CD11b/CD18-mediated neutrophil phagocytosis of nonopsonized microorganisms.

Nakayama, Hitoshi; Yoshizaki, Fumiko; Prinetti, Alessandro; Sonnino, Sandro; Mauri, Laura; Takamori, Kenji; Ogawa, Hideoki; Iwabuchi, Kazuhisa

Nakayama, Hitoshi; Yoshizaki, Fumiko; Prinetti, Alessandro; Sonnino, Sandro; Mauri, Laura; Takamori, Kenji; Ogawa, Hideoki; Iwabuchi, Kazuhisa.

Affiliation

Nakayama H; Institute for Environmental and Gender-Specific Medicine, Juntendo University Graduate School of Medicine, 2-1-1 Tomioka, Urayasu, Chiba 279-0021, Japan.

J Leukoc Biol ; 83(3): 728-41, 2008 Mar.

Article in En | MEDLINE | ID: mdl-18055569

Subject(s)

Antigens, CD/physiology; CD11b Antigen/physiology; CD18 Antigens/physiology; Lactosylceramides/pharmacology; Membrane Microdomains/physiology; Neutrophils/physiology; Phagocytosis/physiology; src-Family Kinases/physiology; Animals; Cell Membrane/physiology; Cell Membrane/ultrastructure; HL-60 Cells; Humans; Mice; Neutrophils/drug effects; Phagocytosis/drug effects; Phagosomes/physiology; Phagosomes/ultrastructure; RNA, Small Interfering/genetics; Zymosan/physiology

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Collection: 01-internacional Database: MEDLINE Main subject: Phagocytosis / Antigens, CD / CD18 Antigens / Src-Family Kinases / Membrane Microdomains / CD11b Antigen / Lactosylceramides / Neutrophils Limits: Animals / Humans Language: En Journal: J Leukoc Biol Year: 2008 Document type: Article Affiliation country: Japan

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