Antineoplastic Agents/pharmacology; Boronic Acids/pharmacology; Enzyme Inhibitors/pharmacology; Neoplasms/drug therapy; Proteasome Inhibitors; Pyrazines/pharmacology; Threonine/analogs & derivatives; Administration, Oral; Animals; Antineoplastic Agents/therapeutic use; Apoptosis/drug effects; Boronic Acids/administration & dosage; Boronic Acids/chemistry; Boronic Acids/therapeutic use; Bortezomib; Cell Line; Cell Proliferation/drug effects; Cell Survival/drug effects; Drug Screening Assays, Antitumor; Endothelial Cells/drug effects; Endothelial Cells/pathology; Enzyme Inhibitors/administration & dosage; Enzyme Inhibitors/chemistry; Enzyme Inhibitors/therapeutic use; Humans; Macrophage Colony-Stimulating Factor/pharmacology; Mice; Mice, Nude; Multiple Myeloma/pathology; NF-kappa B/antagonists & inhibitors; Neoplasms/pathology; Osteogenesis/drug effects; Pyrazines/administration & dosage; Pyrazines/therapeutic use; RANK Ligand/pharmacology; Threonine/administration & dosage; Threonine/chemistry; Threonine/pharmacology; Threonine/therapeutic use; Treatment Outcome; Ubiquitin/antagonists & inhibitors; Xenograft Model Antitumor Assays